Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Diego

Best American Restaurants in Little Italy

Price
Regions
Neighborhoods
Top Rated
Dining Options
Seating Options
Award-winning
Accessibility

129 restaurants available nearby

A photo of Herb & Wood restaurant
4.6
Exceptional(6499)
Price: Expensive
• American • Little Italy
Booked 89 times today
Herb & Wood in San Diego's vibrant Little Italy is a shining example of exquisite American cuisine. Celebrated Chef Brian Malarkey crafts a menu that elevates rustic, wood-fired dishes, blending Mediterranean flair with California's commitment to seasonality and sustainability. Diners rave about the "incredible dinner" experience, showcasing "amazing, flavorful food" and "outstanding service." The ambiance is described as "beautiful" and "welcoming," making every visit memorable. Signature dishes like the pork belly and filet mignon are praised for their exceptional taste. Whether you're celebrating a special occasion or enjoying a night out, Herb & Wood promises a "truly memorable culinary experience."
A photo of Ironside Fish & Oyster restaurant
4.5
Awesome(4571)
Price: Moderate
• American • Little Italy
Booked 120 times today
Ironside Fish & Oyster in San Diego's Little Italy is a quintessential hotspot for authentic American cuisine, seamlessly blending traditional and contemporary flavors. This gem pays homage to its roots in the fishing industry with a mouthwatering menu that features renowned dishes such as the lobster roll and clam chowder, praised for being “chock full of clams.” The vibrant atmosphere and top-notch service are frequently highlighted in reviews, with one diner noting the “excellent experience, food, and ambience.” With a stellar raw bar and an enticing happy hour, Ironside promises a “delightful experience” that diners find irresistible.
A photo of Kettner Exchange restaurant
4.7
Exceptional(1374)
Price: Expensive
• American • Little Italy
Booked 63 times today
Kettner Exchange in Little Italy, San Diego, offers an exceptional Asian fusion experience that is both inventive and authentic. Executive Chef Brian Redzikowski’s creations have earned the restaurant a coveted spot on the Michelin Guide's Bib Gourmand list since 2019, showcasing high-quality meals at accessible prices. Diners rave about the "spicy garlic noodles" and "juicy cheeseburger special," underscoring the delightful fusion of flavors. The rooftop patio with stunning harbor views enhances the dining ambiance, making it perfect for any occasion. Guests frequently praise the "stellar service" and "amazing cocktails," solidifying Kettner Exchange as a must-visit destination for Asian cuisine enthusiasts.
A photo of Coco Maya restaurant
4.5
Awesome(381)
Price: Expensive
• American • Little Italy
Booked 8 times today
Coco Maya in Little Italy, San Diego, is a vibrant cocktail bar that elevates your dining experience with "excellent drinks and ambience." Renowned for its diverse mezcal and tequila selection, this bar seamlessly blends tropical and rum-based cocktails, a hallmark that traces back to its roots at Miss B's Coconut Club. Guests rave about the "perfectly crafted espresso martini," which stands out among their expertly curated beverages. The lively rooftop setting, often accompanied by a DJ, adds a fun and energetic vibe that enhances the entire experience. If you're seeking a memorable cocktail adventure, Coco Maya promises to deliver!
A photo of Petrini's restaurant
4.6
Exceptional(431)
Price: Moderate
• American • Little Italy
Booked 4 times today
Petrini's in San Diego's vibrant Little Italy effortlessly brings authentic American cuisine to life with their exceptional dishes. While known for its Italian roots, the restaurant's dedication to quality and authenticity shines through its American offerings. Diners rave about the "excellent food," with dishes that are "just like homemade," ensuring a genuine American experience. Patrons are drawn not only for the delightful meals but also for the "great atmosphere" and "superb service," making it a beloved neighborhood gem. Whether you’re stopping by for brunch, lunch, or dinner, Petrini's promises a memorable American dining experience that keeps guests coming back.
A photo of CUCINA urbana restaurant
4.8
Exceptional(7121)
Price: Moderate
• American • Banker's Hill
Booked 54 times today
CUCINA urbana in Banker's Hill, San Diego, offers an exceptional American dining experience with a California-inspired twist. Renowned for its "amazing food and ambience," this restaurant seamlessly blends comfort with contemporary flair, creating a warm yet stylish environment. Diners rave about the "fantastic food and service," particularly highlighting the exquisite pasta and woodfire pizzas that are "second to none." The restaurant's wine program is a standout feature, offering an impressive selection that perfectly complements the menu. With attentive staff and a lively atmosphere, CUCINA urbana is the perfect spot for celebrating life events or enjoying a memorable meal.
A photo of Parc Bistro-Brasserie restaurant
4.8
Exceptional(3145)
Price: Moderate
• American • Banker's Hill
Booked 41 times today
Parc Bistro-Brasserie, nestled in the vibrant neighborhood of Banker's Hill in San Diego, is a hidden gem that has earned its place among OpenTable's "100 Best Neighborhood Gems in America for 2021." This charming bistro not only excels in French cuisine but also offers a delightful blend of American flavors, making it a standout choice for those seeking authentic American fare. Diners rave about the "amazing experience" and "excellent food and great service" that make every visit memorable. With a cozy ambiance and a menu that promises both tradition and innovation, Parc Bistro-Brasserie is a must-visit for anyone craving American culinary excellence.
A photo of Cowboy Star restaurant
4.9
Exceptional(4776)
Price: Very Expensive
• American • Downtown
Booked 51 times today
Cowboy Star in downtown San Diego is a gem of Contemporary American cuisine, capturing the essence of regional American heirloom recipes with a modern twist. Their commitment to using locally sourced, natural, and organic ingredients shines through every dish, offering "exceptional quality" that diners rave about. Known for their impeccable service and warm atmosphere, Cowboy Star is celebrated for its perfectly cooked steaks, with one reviewer exclaiming, "the best steakhouse in San Diego, PERIOD." The diverse menu, which includes top-notch wine and cocktails, ensures that every visit is a "memorable and enjoyable experience," making Cowboy Star a must-visit for any steak lover.
A photo of The Henry - Coronado restaurant
4.8
Exceptional(2512)
Price: Moderate
• American • Coronado
Booked 141 times today
The Henry - Coronado is a standout destination for exquisite Cocktail Bar cuisine, offering a vibrant and lively atmosphere that feels like a second home. Situated in the heart of Coronado, it features an inviting bar where "creative cocktails are crafted to perfection," ensuring a delightful experience with every visit. Patrons rave about the "outstanding service" and "lively vibe," making it an ideal spot for social gatherings or unwinding after a long day. Whether you're enjoying a holiday drink or a classic concoction, the bar at The Henry ensures a memorable and authentic cocktail experience that keeps guests coming back for more.
A photo of Books + Records restaurant
4.7
Exceptional(386)
Price: Expensive
• American • Banker's Hill
Booked 68 times today
Books + Records in Banker's Hill, San Diego, is a standout Cocktail Bar, celebrated for its "inventive and creative drinks." Patrons rave about the "perfectly executed" cocktails, including unique infusions like the grey tea drink, described as "delish!" This cocktail haven consistently makes Eater's list of San Diego's Hottest Cocktail Bars, showcasing the mixology mastery of its skilled bartenders. The ambiance is lively, featuring live music that complements the vibrant atmosphere. With "attentive and friendly" service and a menu that pairs perfectly with their drinks, Books + Records offers an unmatched cocktail experience that invites you to savor every sip.

How is content generated

See what locals rave about

From verified diners like you
From verified diners like you

Discover best American restaurants in Little Italy

Discover the vibrant American dining scene in San Diego's Little Italy, where the blend of cultural heritage and culinary innovation creates a memorable gastronomic experience. This bustling neighborhood is home to an array of restaurants that masterfully serve American cuisine with a unique twist, emphasizing local ingredients, sustainable practices, and creative flair. Each establishment prides itself on delivering not only high-quality food but also an ambiance that complements the culinary delights, making every meal a special occasion. Whether you're in the mood for rustic, wood-fired dishes that showcase the Californian ethos of seasonality, or classic American seafood prepared with a contemporary edge, Little Italy has something to tantalize every palate. The area is particularly noted for its excellent service and the ability to maintain a high standard of dining experience that keeps locals and tourists alike coming back for more. From award-winning breweries to farm-to-table eateries, the emphasis on fresh, top-notch ingredients is evident in every dish served. San Diego's Little Italy is not just about food; it's about an experience that combines great cuisine with vibrant street life and picturesque settings. Whether you're planning a casual lunch, a business meeting, or a special celebration, Little Italy's American dining venues promise a feast not just for your taste buds but for all your senses.

  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo