Best Southwest American Restaurants in Medical Center

95 restaurants available nearby

1. Clementine

4.8

Exceptional(506)

Price: Very Expensive

• Mexican • North Central

Booked 8 times today

Clementine, nestled in the heart of North Central, Castle Hills, offers an exquisite journey into Contemporary French/American cuisine, delighting diners with seasonal and innovative dishes. The restaurant, led by Chef John, a 2023 James Beard nominee, consistently wows with its ever-evolving menu and crowd favorites like the Ricotta Cavatelli and Clementine Crunch Bar. Guests rave about the "Feed Me" option, an adventurous five-course experience that "never disappoints" with its "multilayered flavors" and "superb" surprises. The vibrant ambiance, coupled with an expertly curated selection of wines, ensures a dining experience that is both authentic and unforgettable. Clementine truly stands out as one of San Antonio's top culinary destinations.

A photo of Alamo Biscuit Company & Panaderia restaurant

2. Alamo Biscuit Company & Panaderia

4.3

Awesome(9)

Price: Moderate

• Mexican • Northwest

*For reservations over 12, please contact us directly at 210-204-8520. *On the weekend, we only take reservations for parties of 6-12, for questions please contact us directly 210-204-8520.Great hospitality is an extension of great service, taking it to another level. Here at Alamo Biscuit Co., hospitality is a great dining experience that goes far beyond great food and great service. A truly great dining experience is when our guest’s needs are anticipated and met for them, resulting in 100% satisfaction. Our goal is to always strive to make every moment memorable.

A photo of Tu Asador - Castle Hills restaurant

3. Tu Asador - Castle Hills

4.7

Exceptional(140)

Price: Expensive

• Mexican • North Central

Booked 6 times today

Tu Asador - Castle Hills is a top-notch Mexican Steakhouse that takes you on a culinary journey through Northern Mexico's rich flavors. Known for its "authentic representation of flavors passed down through generations," Tu Asador makes dining an experience rather than just a meal. Patrons rave about the "superb food" and "attentive service," with many highlighting the perfectly cooked steaks that are "juicy, flavorful, and made with quality beef." The vibrant atmosphere, complete with live music, enhances the experience, making it a "fun ambiance" for any occasion. It's no surprise that Tu Asador is a favorite among locals and newcomers alike.

A photo of Dave & Buster's - San Antonio (Balcones Heights) restaurant

4. Dave & Buster's - San Antonio (Balcones Heights)

4.5

Awesome(105)

Price: Moderate

• Mexican • Medical Center

Booked 11 times today

Each Dave & Buster’s has more state-of-the-art games than ever, more mouth-watering menu items and the most innovative drinks anywhere. From wings to steaks, we’ve got whatever suits your appetite and our premium bar assures we’re stocked to satisfy! Plus, you can watch your game on one of our massive HDTVs with epic stadium sound.

A photo of 54th Street Restaurant & Drafthouse - The Colonnade restaurant

5. 54th Street Restaurant & Drafthouse - The Colonnade

(0)

Price: Moderate

• Mexican • Medical Center

54th Street was founded in Kansas City, MO by Thomas E. Norsworthy in 1989. He envisioned a place that would accommodate a consistently crowded dining room as well as a lively bar crowd, while offering the quality food and drinks that exceed national chain competitors. At 54th Street, we believe that great food starts with fresh produce, high quality meats and ingredients and meals prepared from scratch. With our amazing range of scratch prepared menu items, we truly have something for everyone. The Five-Four promise is to forever uphold our tradition of serving generous portions of housemade food and drink at an honest price. 54th Street welcomes you for all occasions. Drop in for Happy Hour with friends, celebrate a special occasion, enjoy a family night out or fly solo! Ultimately, it’s your time. Join us, experience 54 and share the 54 experience with others.

A photo of Rock & Brews - San Antonio restaurant

6. Rock & Brews - San Antonio

4.5

Awesome(16)

Price: Moderate

• Mexican • North Central

Booked 7 times today

We have it all! American food, craft beers, signature cocktails, large parties and private dining space, live music, catering, live sports, dog-friendly patios, and more! Rock your taste buds with our American inspired menu boasting creative spins on the standards. Our menu items are prepared from scratch using fresh ingredients from the local community. Wash down our culinary creations with one of our 48+ craft beers on tap from local, national, and international breweries or check out our signature cocktails and extensive bourbon and tequila selections! The restaurant can accommodate sports fanatics and large parties of any size (including family and corporate gatherings, youth sports teams, and rehearsal dinners) in our sizable dining room or on our private patios. The restaurant also features live music, weekday lunch specials, a dog-friendly outdoor patio (ask to see our dog menu), and brunch on the weekends.

7. Kona Grill - North Star

4.3

Awesome(588)

Price: Moderate

• Mexican • North San Antonio

Booked 6 times today

Kona Grill - North Star is a sushi lover's paradise nestled in the vibrant North San Antonio area. Renowned for its "award-winning sushi," this restaurant offers an authentic Japanese dining experience with a touch of contemporary flair. The sushi menu is crafted with precision, using only the freshest ingredients, ensuring each bite is a taste revelation. The Tuna Tartar and the special traditional rolls, described as "10/10!!!" by customers, are must-tries that highlight the exceptional quality and artistry behind each dish. With a polished yet casual atmosphere and impeccable service, Kona Grill is the perfect spot for sushi enthusiasts seeking both quality and authenticity.

A photo of Red Lobster - San Antonio - NW Loop 410 restaurant

8. Red Lobster - San Antonio - NW Loop 410

4.4

Awesome(17)

Price: Moderate

• Mexican • North San Antonio

Booked 1 time today

Elevate your day at Red Lobster, where fun meets fancy and every meal is a celebration. Whether you’re marking a special occasion or treating yourself or your crew, Red Lobster is the perfect place to enjoy all your seafood favorites. Dive into our signature shrimp, wild caught lobster and crab, and more. Plus, a variety of fish and popular non-seafood items like our Cajun Chicken Linguini Alfredo. Looking for a showstopper? Create Your Own Ultimate Feast or select a Live Maine Lobster straight from the tank. Or explore our Daily Deals with a different special available each weekday at a price you’ll love. Toast the day with Signature Cocktails including Lobster Punch and Main Deck Margarita Flights to make any moment feel festive. You won’t want to miss our newest menu items or special promotions like Lobsterfest and Crabfest. Reserve online today. Group Dining, To Go, or Catering options. For parties of 11+, please call.

A photo of Pinstack - San Antonio - Park North restaurant

9. Pinstack - San Antonio - Park North

3.9

Excellent(27)

Price: Moderate

• Mexican • Victoria

Booked 2 times today

Reservations are available in our full-service restaurant or climate-controlled patio. TO ENJOY LANE-SIDE SERVICE WHILE YOU BOWL, RESERVATIONS ARE AVAILABLE AT https://pinstackbowl.com/reserve-lane/. PINSTACK is an upscale, one-of-a-kind entertainment and dining destination. Featuring dishes from pan-seared mahi mahi to our GIANT 36-inch KingPin Pizza, everyone will enjoy eating at PINSTACK. With two fully-stocked bars, PINSTACK is a favorite spot for adults. Choose from 24 draft beers, 12 keg wines, and an extensive list of bottled wine & craft cocktails. The PINSTACK experience doesn't end after dinner! Have fun on the bowling lanes or in the game room, featuring video games, rock climbing wall, high ropes course, laser tag or bumper cars. Weekly Specials: Happy Hour |M-F 4-7 pm | $3 Domestic Pints | $5 Craft Pints | $5 House Wine | $5 House Margaritas Bowl & Bite Mondays | 4-11 pm | 1/2 Price Apps | $3 Draft Beer Wine Down Wednesdays | ALL DAY | 50% off bottles

A photo of Perry's Steakhouse & Grille - San Antonio restaurant

10. Perry's Steakhouse & Grille - San Antonio

4.7

Exceptional(9404)

Price: Expensive

• Mexican • La Cantera

Booked 67 times today

Perry's Steakhouse & Grille - San Antonio is a beacon of authentic American cuisine nestled in the lively La Cantera area. Renowned for its "exceptional" pork chops and "outstanding" service, Perry's offers a dining experience that consistently delights locals and visitors alike. Guests rave about the "juicy, flavorful, and tender" meats, which are expertly crafted by the skilled chefs visible from the spacious, open dining area. The vibrant atmosphere, underscored by the popular Bar 79® with its floor-to-ceiling windows, enhances every visit, making Perry's a top choice for both casual and special occasions. "Perry's never disappoints," ensuring a memorable American culinary experience.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you

F
frank
San Antonio •1 review
5.0
Dined 1 day ago
Met here for an early birthday for my mother who lives in Oklahoma and we all enjoyed the setting and overall flavor profiles of the dishes. The pastry cart is a nice touch.
More info
MezquitePrice: Moderate• Northern Mexican• Downtown
•
4.6
J
James
San Antonio •5 reviews
4.0
Dined 2 days ago
A little less music volume in the place would make it more enjoyable. The service needs some structure. Drinks came late in the middle of the meal. And it was not crowded. The fish tacos were very good as well as the Cabrito and the guacamole went a little too much lime. The Chalupas and the Tacos were just ok. It could do a lot better.
More info
ÁcenarPrice: Moderate• Contemporary Mexican• Downtown
•
4.4
D
Desiree
San Antonio •1 review
5.0
Dined 2 days ago
Beautiful ambiance, especially if you sit outside along the river. The restaurant was quiet where you can hold a conversation and tables are well spaced, so you do not hear others conversations. The value of the food was mediocre; however, you’re paying for the scenery. The service was excellent. My party and I went in the evening. I will definitely come back for brunch soon.
More info
Domingo RestaurantePrice: Expensive• Mexican / Southwestern• Downtown
•
4.5
D
DarlinaVIP
Tampa / Central Florida West •17 reviews
5.0
Dined on Dec 23, 2024
Food and service always great even when over booked. Must try prickly pear margarita
More info
Las Guitarras RestaurantPrice: Moderate• Mexican• Boerne
•
4.7
OT
OpenTable Diner
Houston •35 reviews
5.0
Dined on Jun 7, 2023
Great, quality food. Everyone at our table was very happy with what they got.
More info
Dos Rios Mexican Bar & GrillPrice: Moderate• Mexican• New Braunfels
•
4.5

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Best Southwest American Restaurants in Medical Center

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95 restaurants available nearby

1. Clementine

2. Alamo Biscuit Company & Panaderia

3. Tu Asador - Castle Hills

4. Dave & Buster's - San Antonio (Balcones Heights)

5. 54th Street Restaurant & Drafthouse - The Colonnade

6. Rock & Brews - San Antonio

7. Kona Grill - North Star

8. Red Lobster - San Antonio - NW Loop 410

9. Pinstack - San Antonio - Park North

10. Perry's Steakhouse & Grille - San Antonio

See what locals rave about

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