Best Southern American Restaurants in Little Italy

128 restaurants available nearby

A photo of Ironside Fish & Oyster restaurant

1. Ironside Fish & Oyster

4.4

Price: Moderate

• Southern american • Little Italy

Booked 27 times today

Nestled in the heart of San Diego's vibrant Little Italy, Ironside Fish & Oyster is a gem for seafood enthusiasts. Celebrated for its dedication to the freshest and highest quality seafood, this restaurant has transformed a historic auction house into a bustling seafood haven with an expansive raw bar and open-air culinary hubs. Patrons rave about their "10/10 plump oysters" and assert that the "fish and chips may be the best in San Diego." Not to be missed are their lobster rolls, described as "the best thing I ever had!" With its cool vibe and exceptional service, Ironside Fish & Oyster offers an unforgettable dining experience right by the docks where the city's fishing legacy continues to thrive.

2. Herb & Wood

4.7

Exceptional(6435)

Price: Expensive

• Southern american • Little Italy

Booked 39 times today

Herb & Wood in Little Italy, San Diego, epitomizes the essence of Mediterranean cuisine with a delightful twist of Californian flair. Celebrated Chef Brian Malarkey crafts a menu that transforms simple ingredients into a symphony of flavors, all centered around a wood-fired concept that accentuates each dish's rustic, authentic taste. Reviewers consistently praise the restaurant's vibrant atmosphere and innovative dishes, with one guest exclaiming, "The bone marrow and oyster dish was especially impressive!" and another noting the "swordfish was very fresh and tasty." Herb & Wood not only offers a feast for the taste buds but also a Mediterranean dining experience that is both heartfelt and memorable, making it a culinary jewel in San Diego.

3. Kettner Exchange

4.7

Exceptional(1334)

Price: Expensive

• Southern american • Little Italy

Booked 23 times today

Kettner Exchange in Little Italy, San Diego, is a paragon of Contemporary American cuisine, offering a unique dining experience that reflects the very essence of culinary innovation. With its expansive harbor views from the rooftop patio and the culinary prowess of Executive Chef Brian Redzikowski, the restaurant has consistently wowed diners and critics alike, earning a spot on the Michelin Guide's Bib Gourmand list since 2019. Reviews often highlight the inspired menu, such as one diner’s praise for the “magical” way flavors and textures are combined. Another reviewer raves, “UNBELIEVABLE! THE MOST INCREDIBLE DINING EXPERIENCE OF MY LIFE,” underscoring the exceptional quality and creativity on display. Kettner Exchange's commitment to a thrilling gastronomic journey makes it a must-visit for those seeking the best in Contemporary American fare.

4. Coco Maya

4.7

Exceptional(375)

Price: Expensive

• Southern american • Little Italy

Booked 3 times today

Coco Maya in Little Italy, San Diego, is a delightful revelation in Contemporary American cuisine, offering a creative twist on classic American fare. The restaurant's use of a traditional Spanish-style coal-fired Josper oven brings a unique flavor profile to robust, flavorful proteins, setting it apart in a neighborhood rich with culinary offerings. Reviewers rave about the diverse menu, highlighting dishes like the "delicious" short rib pasta and "amazing" skirt steak. The ambiance, enhanced by sweeping views of Little Italy and a vibrant rooftop setting, is consistently praised. It’s not just the food that receives acclaim; the cocktail program, featuring a diverse mezcal and tequila selection, is also a highlight. Visitors describe their dining experience as “unforgettable,” noting the "fun atmosphere" and exceptional service that make Coco Maya a must-visit spot in San Diego.

5. Petrini's

4.5

Awesome(424)

Price: Moderate

• Southern american • Little Italy

Petrini's in San Diego's vibrant Little Italy is a culinary gem, celebrated for its exceptional American cuisine with a unique twist. This eatery stands out for its dedication to quality and authenticity, drawing diners back time and again. Guests rave about the "delicious and homemade tasting" dishes, highlighting the smoked salmon alfredo and the innovative diablo shrimp as must-tries. The restaurant's atmosphere is consistently praised, with one visitor noting it as a "quiet, quaint, and beautiful eatery with old world recipes." Petrini's commitment to excellence is evident in every dish, making it a top destination for those seeking authentic American flavors in San Diego.

6. Cowboy Star

4.9

Exceptional(4725)

Price: Very Expensive

• Southern american • Downtown

Booked 30 times today

Cowboy Star in the vibrant heart of Downtown San Diego epitomizes the essence of Contemporary American cuisine with a wild-west twist. Celebrated for its dedication to regional heirloom recipes and superior service, Cowboy Star stands out for its use of local, natural, and organic ingredients, ensuring every dish sings with authenticity and freshness. The menu showcases exceptional dishes, such as the Niman Ranch all-natural beef, earning it rave reviews for the "best steak in SD" and a culinary experience that is both genuine and heartwarming. Diners consistently praise the "excellent vibe" and "impeccable service," making it a must-visit for anyone seeking the pinnacle of Contemporary American dining in San Diego.

7. CUCINA urbana

4.7

Exceptional(7085)

Price: Moderate

• Southern american • Banker's Hill

Booked 11 times today

Nestled in the vibrant Bankers Hill neighborhood of San Diego, CUCINA urbana offers a sublime blend of American cuisine with a unique twist. This gem has been delighting patrons since 2009, merging a cozy farmhouse vibe with a modern art installation, making each dining experience both comforting and visually stimulating. The restaurant's dedication to quality is evident, with diners raving about the "stellar" food and "exceptional" service. Highlights include the meatballs with a "spicy" kick and the perfectly cooked rigatoni, not to mention the "spectacular" desserts like tiramisu and limoncello mousse tart. The innovative wine program allows guests to select from a range of both familiar and rare vintages at retail prices, enhancing meals or to enjoy at home. CUCINA urbana isn't just a meal; it's a culinary celebration in the heart of San Diego.

8. Books + Records

4.7

Exceptional(367)

Price: Expensive

• Southern american • Banker's Hill

Booked 4 times today

Books + Records in Banker's Hill, San Diego, is not just a place to dine; it's an experience of culinary and mixological artistry. Renowned for its craft cocktails, this spot stands out with creations like the "Purple Rain," a unique blend of Japanese whisky that captures the essence of the restaurant's innovative approach to drinks. Praised for its vibrant atmosphere and live music that complements every sip, Books + Records has been featured on Eater's Heat Map and listed among San Diego's Hottest Cocktail Bars. Guests continuously rave about the quality, with one noting, "The cocktails were delish," underscoring the establishment's commitment to excellence in every glass. Whether you're in for the live jazz or the acclaimed "old-fashioned," Books + Records delivers an unforgettable cocktail bar experience.

A photo of Parc Bistro-Brasserie restaurant

9. Parc Bistro-Brasserie

4.8

Exceptional(3082)

Price: Moderate

• Southern american • Banker's Hill

Booked 24 times today

Parc Bistro-Brasserie, nestled in the heart of Bankers Hill, San Diego, is a celebrated haven of French cuisine, meriting its spot on OpenTable’s “100 Best Neighborhood Gems in America for 2021.” Renowned for its seafood-focused approach, the bistro expertly balances classic French dishes with global inspirations. Patrons rave about the "outstanding jumbo shrimp cocktail & steak frites" and the brunch that has been crowned as the "Best Brunch in San Diego." The allure of Parc Bistro-Brasserie is enhanced by its "exceptional food" and ambiance that transforms a meal into a "Paris escape." With glowing reviews like "By far my favorite French restaurant in San Diego! The food is superb!", it's clear that Parc Bistro-Brasserie is a culinary gem that continuously captivates both locals and visitors alike.

A photo of Water Grill - San Diego restaurant

10. Water Grill - San Diego

4.7

Exceptional(3581)

Price: Expensive

• Southern american • Downtown

Booked 44 times today

Nestled in the vibrant heart of San Diego's Gaslamp District, Water Grill San Diego offers an unparalleled seafood experience that has consistently earned it top ratings among the city’s seafood dining spots. Right from the bustling docks, their boat-to-table strategy ensures only the freshest seafood, including an impressive variety of fish, lobsters, crabs, and oysters, makes it to your plate, often within hours of being caught. Patrons rave about their 'exceptional' seafood dishes, with the Chilean seabass and lobster frequently highlighted as 'possibly the best ever had.' Each dish is crafted to showcase the natural flavors of the high-quality ingredients, earning glowing reviews for both the culinary finesse and the lively, elegant ambiance. Whether it's the 'amazing' oyster sampler or the expertly prepared sea bass, Water Grill promises a memorable dining adventure right in the bustling center of San Diego.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

Explore OpenTable

Little Italy

Southern american

Best Southern American Restaurants in Little Italy

Price

Regions

Neighborhoods

Top Rated

Dining Options

Seating Options

Award-winning

Accessibility

128 restaurants available nearby

1. Ironside Fish & Oyster

2. Herb & Wood

3. Kettner Exchange

4. Coco Maya

5. Petrini's

6. Cowboy Star

7. CUCINA urbana

8. Books + Records

9. Parc Bistro-Brasserie

10. Water Grill - San Diego

Explore OpenTable