Best Southern American Restaurants in Little Italy

126 restaurants available nearby

1. Herb & Wood

4.7

Exceptional(6494)

Price: Expensive

• Southern american • Little Italy

Booked 85 times today

Herb & Wood in San Diego's vibrant Little Italy is a shining example of exquisite American cuisine. Celebrated Chef Brian Malarkey crafts a menu that elevates rustic, wood-fired dishes, blending Mediterranean flair with California's commitment to seasonality and sustainability. Diners rave about the "incredible dinner" experience, showcasing "amazing, flavorful food" and "outstanding service." The ambiance is described as "beautiful" and "welcoming," making every visit memorable. Signature dishes like the pork belly and filet mignon are praised for their exceptional taste. Whether you're celebrating a special occasion or enjoying a night out, Herb & Wood promises a "truly memorable culinary experience."

A photo of Ironside Fish & Oyster restaurant

2. Ironside Fish & Oyster

4.5

Awesome(4565)

Price: Moderate

• Southern american • Little Italy

Booked 118 times today

Ironside Fish & Oyster in San Diego's Little Italy is a quintessential hotspot for authentic American cuisine, seamlessly blending traditional and contemporary flavors. This gem pays homage to its roots in the fishing industry with a mouthwatering menu that features renowned dishes such as the lobster roll and clam chowder, praised for being “chock full of clams.” The vibrant atmosphere and top-notch service are frequently highlighted in reviews, with one diner noting the “excellent experience, food, and ambience.” With a stellar raw bar and an enticing happy hour, Ironside promises a “delightful experience” that diners find irresistible.

3. Kettner Exchange

4.7

Exceptional(1371)

Price: Expensive

• Southern american • Little Italy

Booked 66 times today

Kettner Exchange in Little Italy, San Diego, offers an exceptional Asian fusion experience that is both inventive and authentic. Executive Chef Brian Redzikowski’s creations have earned the restaurant a coveted spot on the Michelin Guide's Bib Gourmand list since 2019, showcasing high-quality meals at accessible prices. Diners rave about the "spicy garlic noodles" and "juicy cheeseburger special," underscoring the delightful fusion of flavors. The rooftop patio with stunning harbor views enhances the dining ambiance, making it perfect for any occasion. Guests frequently praise the "stellar service" and "amazing cocktails," solidifying Kettner Exchange as a must-visit destination for Asian cuisine enthusiasts.

4. Coco Maya

4.5

Awesome(379)

Price: Expensive

• Southern american • Little Italy

Booked 6 times today

Coco Maya in Little Italy, San Diego, is a vibrant cocktail bar that elevates your dining experience with "excellent drinks and ambience." Renowned for its diverse mezcal and tequila selection, this bar seamlessly blends tropical and rum-based cocktails, a hallmark that traces back to its roots at Miss B's Coconut Club. Guests rave about the "perfectly crafted espresso martini," which stands out among their expertly curated beverages. The lively rooftop setting, often accompanied by a DJ, adds a fun and energetic vibe that enhances the entire experience. If you're seeking a memorable cocktail adventure, Coco Maya promises to deliver!

5. Petrini's

4.5

Awesome(430)

Price: Moderate

• Southern american • Little Italy

Booked 3 times today

Petrini's in San Diego's vibrant Little Italy effortlessly brings authentic American cuisine to life with their exceptional dishes. While known for its Italian roots, the restaurant's dedication to quality and authenticity shines through its American offerings. Diners rave about the "excellent food," with dishes that are "just like homemade," ensuring a genuine American experience. Patrons are drawn not only for the delightful meals but also for the "great atmosphere" and "superb service," making it a beloved neighborhood gem. Whether you’re stopping by for brunch, lunch, or dinner, Petrini's promises a memorable American dining experience that keeps guests coming back.

6. CUCINA urbana

4.8

Exceptional(7119)

Price: Moderate

• Southern american • Banker's Hill

Booked 56 times today

CUCINA urbana in Banker's Hill, San Diego, offers an exceptional American dining experience with a California-inspired twist. Renowned for its "amazing food and ambience," this restaurant seamlessly blends comfort with contemporary flair, creating a warm yet stylish environment. Diners rave about the "fantastic food and service," particularly highlighting the exquisite pasta and woodfire pizzas that are "second to none." The restaurant's wine program is a standout feature, offering an impressive selection that perfectly complements the menu. With attentive staff and a lively atmosphere, CUCINA urbana is the perfect spot for celebrating life events or enjoying a memorable meal.

A photo of Parc Bistro-Brasserie restaurant

7. Parc Bistro-Brasserie

4.8

Exceptional(3141)

Price: Moderate

• Southern american • Banker's Hill

Booked 52 times today

Parc Bistro-Brasserie, nestled in the vibrant neighborhood of Banker's Hill in San Diego, is a hidden gem that has earned its place among OpenTable's "100 Best Neighborhood Gems in America for 2021." This charming bistro not only excels in French cuisine but also offers a delightful blend of American flavors, making it a standout choice for those seeking authentic American fare. Diners rave about the "amazing experience" and "excellent food and great service" that make every visit memorable. With a cozy ambiance and a menu that promises both tradition and innovation, Parc Bistro-Brasserie is a must-visit for anyone craving American culinary excellence.

8. Cowboy Star

4.9

Exceptional(4767)

Price: Very Expensive

• Southern american • Downtown

Booked 58 times today

Cowboy Star in downtown San Diego is a gem of Contemporary American cuisine, capturing the essence of regional American heirloom recipes with a modern twist. Their commitment to using locally sourced, natural, and organic ingredients shines through every dish, offering "exceptional quality" that diners rave about. Known for their impeccable service and warm atmosphere, Cowboy Star is celebrated for its perfectly cooked steaks, with one reviewer exclaiming, "the best steakhouse in San Diego, PERIOD." The diverse menu, which includes top-notch wine and cocktails, ensures that every visit is a "memorable and enjoyable experience," making Cowboy Star a must-visit for any steak lover.

9. Books + Records

4.7

Exceptional(385)

Price: Expensive

• Southern american • Banker's Hill

Booked 46 times today

Books + Records in Banker's Hill, San Diego, is a standout Cocktail Bar, celebrated for its "inventive and creative drinks." Patrons rave about the "perfectly executed" cocktails, including unique infusions like the grey tea drink, described as "delish!" This cocktail haven consistently makes Eater's list of San Diego's Hottest Cocktail Bars, showcasing the mixology mastery of its skilled bartenders. The ambiance is lively, featuring live music that complements the vibrant atmosphere. With "attentive and friendly" service and a menu that pairs perfectly with their drinks, Books + Records offers an unmatched cocktail experience that invites you to savor every sip.

A photo of Water Grill - San Diego restaurant

10. Water Grill - San Diego

4.7

Exceptional(3608)

Price: Expensive

• Southern american • Downtown

Booked 52 times today

Water Grill - San Diego is a standout destination for exceptional American cuisine, offering an authentic seafood experience in the vibrant Gaslamp District. Known for its "first catch of the season" approach, the restaurant excels in delivering fresh, high-quality seafood that arrives boat-to-table in mere hours. Diners rave about the "perfection" of the dishes, with standout menu items like the Chilean Sea Bass and the lobster roll receiving glowing praise. The service is consistently top-notch, with patrons applauding the attentive and knowledgeable staff. Whether for a romantic date or a business meeting, Water Grill promises a memorable culinary adventure.

‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

Explore OpenTable

Little Italy

Southern american

Best Southern American Restaurants in Little Italy

Price

Regions

Neighborhoods

Top Rated

Dining Options

Seating Options

Award-winning

Accessibility

126 restaurants available nearby

1. Herb & Wood

2. Ironside Fish & Oyster

3. Kettner Exchange

4. Coco Maya

5. Petrini's

6. CUCINA urbana

7. Parc Bistro-Brasserie

8. Cowboy Star

9. Books + Records

10. Water Grill - San Diego

Explore OpenTable