Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Antonio

Best Comfort Food Restaurants in Medical Center

Price
Cuisine
Regions
Neighborhoods
Top Rated
Dining Options
Seating Options
Accessibility

15 restaurants available nearby

A photo of Whiskey Cake - San Antonio restaurant
4.7
Exceptional(4253)
Price: Moderate
• Farm-to-table • La Cantera
Booked 116 times today
Whiskey Cake in San Antonio is a comfort food haven. The restaurant's approachable menu features New American comfort food, sourcing as much as possible locally. Signature dishes include slow-cooked meats and the famous whiskey cake for dessert. The farm-to-fork mission is evident in the fresh, high quality ingredients. Reviewers consistently mention the 'comfort food' options, 'fresh and light yet feel like comfort foods', and 'great food always consistent with awesome flavors'. The restaurant's inviting atmosphere, great service, and unique menu add to the comfort food experience.
A photo of Best Quality Daughter restaurant
4.9
Exceptional(560)
Price: Moderate
• Unspecified • Downtown
Booked 70 times today
Best Quality Daughter houses a vibrant, chic décor and new, unique Asian-American menu. In 2018, chef Jennifer Hwa Dobbertin, wanting to address the sparsity of Asian-American female chefs in South Texas, developed a new concept through a series of pop-up dinners called Best Quality Daughter with fellow chef Anne Ng and artist Jennifer Ling Datchuk. Today Best Quality Daughter is located in the historic Mueller House at the Pearl Brewery. Curated by chef Jennifer Hwa Dobbertin, Best Quality Daughter's menu takes inspiration from her travels and the comfort food of her youth as a second-generation Chinese-American.
A photo of Ambler - Texas Kitchen + Cocktails restaurant
4.2
Awesome(579)
Price: Moderate
• Contemporary American • Downtown
Booked 7 times today
Ambler - Texas Kitchen + Cocktails is a comfort food haven with its 'fantastic service' and 'superb meals' praised by reviewers. The 'great food', 'great atmosphere' and 'friendly staff' make it a 'comfortable' spot. The menu, inspired by Texas, boasts 'jaw-dropping views' and 'vibrant flavors'. From 'exotic menu' to 'excellent food and cocktails', Ambler is the perfect spot for a comforting meal.
A photo of Brasserie Mon Chou Chou restaurant
4.8
Exceptional(3453)
Price: Moderate
• French • Downtown
Booked 36 times today
Brasserie Mon Chou Chou is a vibrant place, bustling with energy and celebrated food prepared in a French style, with free-flowing drinks and people connecting over the every day and the special. We feature quintessential French comfort food that showcases simple, earthy, flavorful dishes from regions throughout France. Brasserie Mon Chou Chou is located in the Pearl district near the entrance of the hotel Emma at 312 Pearl Parkway Building 2, Suite 2104, in the space formerly occupied by The Culinary Institute of America's Nao. "Mon Chou Chou" is an affectionate French nickname given to a person who is special to you. Usually a person of unmatched care, love, and beauty who makes your world "go round".
A photo of Carriqui restaurant
4.7
Exceptional(749)
Price: Expensive
• Unspecified • Downtown
Booked 40 times today
COOKING WITH FIRE, SOUTH TEXAS STYLE Carriqui celebrates the South Texas tradition of drawing flavor from fire. Inspired by the flight path of our namesake bird, our menus feature regional favorites from the Rio Grande Valley, Texas coast, and the Hill Country. Nearly every dish is touched by the glowing embers of our custom-forged pits, smoker, or grill, all fueled by native wood. Along with housemade tortillas, cold margaritas, and warm hospitality, each meal is an opportunity to experience the vibrant food and spirit of our South Texas culture.
A photo of Sustenio - Eilan Hotel restaurant
3.0
Good(692)
Price: Moderate
• Southwest • La Cantera
Booked 3 times today
Enjoy the diverse flavors of South Texas at Sustenio! Local fresh produce and proteins brought in daily; with influences from Traditional Mexico, Creole and Southern Comfort foods.
A photo of Tokyo Cowboy restaurant
4.6
Exceptional(256)
Price: Expensive
• Tapas / Small Plates • Downtown
Booked 23 times today
Asian-inspired diner with creative cocktails and a great selection of whisky!
A photo of Joe's Crab Shack - San Antonio restaurant
3.2
Good(28)
Price: Moderate
• Seafood • Downtown
Booked 10 times today
Joe’s Crab Shack offers a variety of favorites from all parts of the sea and shore. From its extensive menu, guests can choose from buckets of seasonal seafood, fried shrimp platters and fish dishes, as well as options from the “mainland” that include steak, sandwiches, and chicken. Guests can indulge in over-sized and creative cocktails, such as the Shark Bite which is playfully garnished with a shark toy. Since its inception, Joe’s popularity has stemmed not only from its menu, but also its retail store. With various pieces of merchandise for purchase, including the ever-popular tie-dye T-shirt with the phrase “Peace, Love and Crabs,” Joe’s has become synonymous with the word “fun.”
A photo of Bazille – Nordstrom La Cantera restaurant
4.6
Exceptional(101)
Price: Moderate
• Contemporary American • La Cantera
Booked 4 times today
Bold flavors elevate beloved bistro classics in chic and inviting Bazille. Meet up with friends at the bar for internationally sourced wines and handcrafted cocktails. Stay for appetizers, salads, brick-oven pizzas and our tempting housemade desserts.The Bazille is located on level 2 inside Nordstrom at The Shops at La Cantera. Join us for Brunch on weekends.
A photo of Esquire Tavern restaurant
4.5
Awesome(655)
Price: Expensive
• American • Downtown
Booked 16 times today
Located in the heart of downtown, The Esquire Tavern is the oldest bar on the San Antonio Riverwalk, opened the year, month and day that Prohibition was repealed. Tending bar in the early days was a highly prized and much sought after craft. Bar keeps then created many of their own syrups, mixes and concoctions and used the freshest of juices with the intention of serving the best products. We at the Esquire have taken a serious approach to the old world of bartending and spun it with a modern twist. Combining classic techniques and new world flavors and culinary concepts, our goal is to lead and set San Antonio's emerging cocktail culture on the map.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you
  • Lauren
    Dallas - Fort Worth •4 reviews
    5.0
    Dined 2 days ago
    Best meal I’ve had in a long time. Super appreciated the waitress asking about allergies and having swaps ready for our seafood allergic friend. The vibe was exquisite. Beautiful wall paper and decor. I felt inspired not only by the food but by the ambiance as well.
    More info
    Best Quality DaughterPrice: Moderate• Unspecified• Downtown
    4.9
  • James
    San Antonio •13 reviews
    5.0
    Dined 3 days ago
    Our waiter was the highlight of the meal & experience! The let down was the food, took longer than normal but it was Valentine’s Day. The chicken & cheese was nothing like the original version, this one was dry and lacked flavor. The meat & cheese board was 1/2 the size of the original one they use to do and didn’t have anything spectacular one. We passed on dessert because we’d already been there for 2 hours. Kudos to the waiter who did an amazing job with service, might give y’all another try because of him.
    More info
    Whiskey Cake - San AntonioPrice: Moderate• Farm-to-table• La Cantera
    4.7
  • Sandra
    Denver / Colorado •2 reviews
    5.0
    Dined 3 days ago
    Our Valentines dinner was perfect in every regard! Francisco our server was attentive, the food was delicious and the ambiance ( fireside) was exquisite. They even provided the ladies with a rose. After dinner a rousing Mexican band was playing. Couldn’t have put together a better evening!
    More info
    Ambler - Texas Kitchen + CocktailsPrice: Moderate• Contemporary American• Downtown
    4.2
  • MichelleVIP
    Tulsa •5 reviews
    5.0
    Dined 3 days ago
    This place is lovely! The service is in incredible and the ambiance is perfect! Food is delicious. I recommend the Brussel sprouts. We went for Valentine’s Day and it was raining, the staff quickly accommodated for all the outside reservations. We were thankful not to have to sit outside in the rain. Jerrell, our waiter, WAS AMAZING AND SO KIND.
    More info
    CarriquiPrice: Expensive• Unspecified• Downtown
    4.7
  • Andy
    Washington, D.C. Area •3 reviews
    5.0
    Dined 4 days ago
    Loved the food and wine selection at Mon Chou! Service was exceptional and host staff was very friendly! Prices were all reasonably. Highly recommend for anyone visiting San Antonio based on its amazing location in the Pearl!
    More info
    Brasserie Mon Chou ChouPrice: Moderate• French• Downtown
    4.8
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo